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Cases J. 2009 Jul 2;2:7965. doi: 10.4076/1757-1626-2-7965.

Metastatic adenocarcinoma within a functioning adrenal adenoma: a case report.

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Department of Surgery, Hospital of St. Raphael 1450 Chapel Street, New Haven, CT 06511 USA.


We present the case of a 54-year-old woman who underwent right adrenalectomy for palliation of Cushing's symptoms. She had recently been diagnosed with lung adenocarcinoma. Pathologic findings revealed a 5 cm adrenal adenoma with a metastatic adenocarcinoma deposit. The occurrence of tumor-to-tumor metastasis is rare, and the finding of a metastasis within a functional adrenal adenoma exceptionally so. Previously reported incidences of this finding in patients with lung cancer range from 0.14% to 0.63%. We review the literature regarding this unusual finding.

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