Format

Send to

Choose Destination
Beijing Da Xue Xue Bao Yi Xue Ban. 2009 Oct 18;41(5):578-84.

[Flavonoids from Scutellaria baicalensis and their bioactivities].

[Article in Chinese]

Author information

1
State Key Laboratory of Natural and Biomimetic Drugs, Peking University School of Pharmaceutical Sciences, Beijing 100191, China.

Abstract

OBJECTIVE:

To study the flavonoids of Scutellaria baicalensis and their bioactivities.

METHODS:

Chromatographic methods were used to separate compounds, spectral methods were used to determine the structures and bioactivities of the flavonoids were screened in several models in vitro.

RESULTS:

Nine compounds were isolated and identified as baicalein (1), wogonin (2), oroxylin A (3), 5, 7, 2', 6'-tetrahydroxyflavone (4), viscidulin III (5), baicalin (6), wogonoside (7), oroxylin A-7-O-beta-D-glucuronide (8) and chrysin-6-C-alpha-L-arabinopyranosyl-8-C-beta-D-glucopyranoside (9).

CONCLUSION:

Baicalein had good anti-bacteria activity, and some compounds showed inhibiting activity against IL-1beta converting enzyme. The 13C NMR data of compounds 9 were assigned correctly by 2D nuclear magnetic resonance (NMR).

PMID:
19829679
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Journal of Peking University (Health Sciences)
Loading ...
Support Center