Format

Send to

Choose Destination
Nature. 2009 Oct 15;461(7266):900-7. doi: 10.1038/nature08536.

Molecular genetics and imaging technologies for circuit-based neuroanatomy.

Author information

1
Department of Neurobiology, Duke University Medical Center, Box 3209, Durham, North Carolina 27710, USA.

Abstract

Brain function emerges from the morphologies, spatial organization and patterns of connectivity established between diverse sets of neurons. Historically, the notion that neuronal structure predicts function stemmed from classic histological staining and neuronal tracing methods. Recent advances in molecular genetics and imaging technologies have begun to reveal previously unattainable details about patterns of functional circuit connectivity and the subcellular organization of synapses in the living brain. This sophisticated molecular and genetic 'toolbox', coupled with new methods in optical and electron microscopy, provides an expanding array of techniques for probing neural anatomy and function.

PMID:
19829369
PMCID:
PMC2884271
DOI:
10.1038/nature08536
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center