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Cell Cycle. 2009 Nov 1;8(21):3474-9. Epub 2009 Nov 18.

Paradoxical roles of FAK in tumor cell migration and metastasis.

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1
Brain Tumor Center and Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Abstract

Focal adhesion kinase (FAK), as a key mediator of signaling induced by integrins, plays an instrumental role in many cellular functions, including cell survival and proliferation. Many studies have reported that FAK is a positive regulator of normal cell migration and cancer cell metastasis. However, emerging evidence shows that FAK--under certain oncogenic signaling, such as that initiated by activated Ras and some growth factor receptor kinases--negatively regulates cancer cell migration. Activated Ras may promote tumor cell migration by dephosphorylation of FAK at Y397 and facilitation of focal adhesion turnover at the leading edge of cells.

PMID:
19829089
DOI:
10.4161/cc.8.21.9846
[Indexed for MEDLINE]
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