Format

Send to

Choose Destination
RNA Biol. 2009 Nov-Dec;6(5):526-30. Epub 2009 Nov 18.

Spliceosomes walk the line: splicing errors and their impact on cellular function.

Author information

1
Department of Microbiology & Molecular Genetics, University of California, Irvine, CA, USA.

Abstract

The splicing of nuclear pre-mRNAs is a fundamental process required for the expression of most metazoan genes. The majority of the approximately 25,000 genes encoded by the human genome has been shown to produce more than one kind of transcripts through alternative splicing. Alternative splicing of pre-mRNAs can lead to the production of multiple protein isoforms from a single gene, significantly enriching the proteomic diversity of higher eukaryotic organisms. Because regulation of this process determines the timing and location that a particular protein isoform is produced, changes of alternative splicing patterns have the potential to modulate many cellular activities. Consequently, pre-mRNA splicing must occur with a high degree of specificity and fidelity to ensure the appropriate expression of functional mRNAs. Here we review recent progress made in understanding the extent of alternative splicing within the human genome with particular emphasis on splicing fidelity.

PMID:
19829058
PMCID:
PMC3912188
DOI:
10.4161/rna.6.5.9860
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Taylor & Francis Icon for PubMed Central
Loading ...
Support Center