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Eur Surg Res. 2009;43(4):354-9. doi: 10.1159/000247061. Epub 2009 Oct 14.

A new technique for inducing and releasing obstructive jaundice in rats.

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1
7th Surgical Department, Ankara Numune Teaching and Research Hospital, Ankara, Turkey. mtoruc @ yahoo.com

Abstract

AIM:

It was the aim of this study to develop a simple, effective and reversible model of obstructive jaundice in rats.

MATERIAL AND METHOD:

Totally, 24 rats were divided into 3 groups: the sham group including sham-operated control rats who underwent laparotomy only (n = 8), the common bile duct standard ligation technique (CBD-SL) group including rats with CBD ligation using silk (n = 8), and the CBD new ligation technique (CBD-NL) group consisting of rats with CBD ligation by a new technique (n = 8). After release of the ligations, the CBD-SL group continued as the CBD-SL releasing group, and the CBD-NL group as the CBD-NL releasing group.

RESULTS:

It was observed that all the CBD ligated rats were both clinically and biochemically jaundiced but they were relieved after reversing the procedure.

CONCLUSION:

We present a simple, effective and reliable rat model which is suitable for studies which require a reversal of obstructive jaundice in rats.

PMID:
19828959
DOI:
10.1159/000247061
[Indexed for MEDLINE]
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