Format

Send to

Choose Destination
See comment in PubMed Commons below
Trends Mol Med. 2009 Nov;15(11):501-9. doi: 10.1016/j.molmed.2009.09.004. Epub 2009 Oct 12.

Emerging biology of vascular wall progenitor cells in health and disease.

Author information

1
Institute of Anatomy, University Hospital Essen, Essen, Germany.

Abstract

New blood vessels are formed through angiogenesis and postnatal vasculogenesis. Thus, it is essential to identify vascular stem and progenitor cell niches and the mechanisms governing their role in blood vessel formation. Although much is known about circulating and bone marrow-derived endothelial progenitor cells (EPCs), little is known about the vascular wall as an EPC niche. Experimental evidence strongly suggests that EPCs, as well as other stem and progenitor cells, reside in distinct zones of the vessel wall, such as within the subendothelial space and in the so-called "vasculogenic zone" within the vascular adventitia. In this review, we discuss the potential implications of different types of vascular wall resident stem and progenitor cells in health and disease.

PMID:
19828379
DOI:
10.1016/j.molmed.2009.09.004
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center