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Expert Rev Anticancer Ther. 2009 Oct;9(10):1467-72. doi: 10.1586/era.09.87.

Use of lung cancer risk models in planning research and service programs in CT screening for lung cancer.

Author information

1
Cancer Research UK Centre for EMS, Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK. s.w.duffy@qmul.ac.uk

Abstract

Computed tomography screening for lung cancer is now being tested in a number of international trials. The long-term success of the approach in the future National Screening Programme is dependent upon identifying populations at sufficient risk of lung cancer that the benefit-harm ratio of the intervention is likely to be high. There are a number of lung cancer risk prediction models currently available. We review these, and demonstrate, using the Liverpool Lung Project risk prediction model as a case study, the potential for use of a risk prediction model in the design of a randomized trial of lung cancer screening and in the planning of a service screening program.

PMID:
19828008
DOI:
10.1586/era.09.87
[Indexed for MEDLINE]

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