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Fitoterapia. 2010 Jun;81(4):289-95. doi: 10.1016/j.fitote.2009.10.002. Epub 2009 Oct 13.

Ocotea quixos Lam. essential oil: in vitro and in vivo investigation on its anti-inflammatory properties.

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Department of Pharmacological, Biological and Chemical Applied Sciences, University of Parma, Via GP Usberti 27/a, 43100 Parma, Italy.


Here we investigated the anti-inflammatory properties of Ocotea quixos essential oil and of its main components, trans-cinnamaldehyde and methyl cinnamate, in in vitro and in vivo models. Ocotea essential oil and trans-cinnamaldehyde but not methyl cinnamate significantly reduced LPS-induced NO release from J774 macrophages at non-toxic concentrations, inhibited LPS-induced COX-2 expression and increased forskolin-induced cAMP production. The essential oil (30-100mg/kg os) and trans-cinnamaldehyde (10mg/kg os) in carrageenan-induced rat paw edema showed anti-inflammatory effect without damaging gastric mucosa. In conclusion we provide the first evidence of a significant anti-inflammatory gastro-sparing activity of O.quixos essential oil.

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