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Clin Nephrol. 2009 Oct;72(4):312-4.

Renal AA amyloidosis secondary to morbid obesity?

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1
Hospital Universitari Arnau de Vilanova, Lleida, Spain.

Abstract

Systemic amyloidosis is characterized by extracellular deposits on different organs of insoluble fibrils compounded of low molecular weight subunits coming from a great diversity of serum proteins. Secondary amyloidosis AA is due to fibril deposition composed of fragments of the acute phase reactant serum amyloid A. We report a case of a young patient with morbid obesity and hypertension who was admitted to our hospital for acute renal insufficiency associated with nephrotic range proteinuria which developed while on antibiotic treatment for a respiratory infection. AA Amyloidosis was diagnosed by renal biopsy. Based on recent evidence we hypothesize that morbid obesity could be the underlying cause of the deposit disease.

PMID:
19825338
DOI:
10.5414/cnp72312
[Indexed for MEDLINE]

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