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Trends Genet. 1990 Dec;6(12):416-21.

Imprinting a determined state into the chromatin of Drosophila.

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Zentrum für Molekulare Biologie, Universität Heidelberg, FRG.


The Polycomb gene of Drosophila melanogaster is a member of a class of genes involved in the clonal transmission of the repressed state of bomeotic regulatory genes through development. Genetic evidence, and the finding of a molecular similarity between the Polycomb protein and a heterochromatin-associated protein of Drosophila, suggest that this mechanism of repression might be imprinted in the structure of the chromatin, rather than being sustained through the action of diffusible regulatory factors.

[Indexed for MEDLINE]

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