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Cell Mol Life Sci. 2010 Jan;67(2):239-53. doi: 10.1007/s00018-009-0163-7. Epub 2009 Oct 13.

Key factors in mTOR regulation.

Author information

1
Department of Cell Biology, School of Basic Medical Sciences, Southern Medical University, 510515, Guangzhou, China, xiaochunbai@yahoo.com.cn

Abstract

Mammalian target of rapamycin (mTOR) is a protein serine/threonine kinase that controls a wide range of growth-related cellular processes. In the past several years, many factors have been identified that are involved in controlling mTOR activity. Those factors in turn are regulated by diverse signaling cascades responsive to changes in intracellular and environmental conditions. The molecular connections between mTOR and its regulators form a complex signaling network that governs cellular metabolism, growth and proliferation. In this review, we discuss some key factors in mTOR regulation and mechanisms by which these factors control mTOR activity.

PMID:
19823764
PMCID:
PMC4780839
DOI:
10.1007/s00018-009-0163-7
[Indexed for MEDLINE]
Free PMC Article

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