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Bull Cancer. 2009 Nov;96(11):E66-72. doi: 10.1684/bdc.2009.0959.

Implication of HIC1 (Hypermethylated In Cancer 1) in the DNA damage response.

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CNRS-UMR 8161, Institut de Biologie de Lille, Universit├ę de Lille-Nord de France, Institut Pasteur de Lille, IFR 142, 1, rue Calmette, BP447, 59017, Lille Cedex, France.


HIC1 (Hypermethylated In Cancer 1) is a tumor suppressor gene which is epigenetically inactivated in many human cancers. HIC1 encodes a transcriptional repressor comprising an N-terminal BTB/POZ domain and a C-terminal DNA binding domain containing five Kr├╝ppel-like C(2)H(2) zinc fingers. To date, few HIC1 target genes are known and the regulation of HIC1 activity is not fully deciphered. However, a growing list of studies, summarized in this review, strongly suggest that HIC1 plays a central role in the DNA damage response through the establishment of several complex regulatory loops involving HIC1, p53, SIRT1 and E2F1.

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