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Neurosci Biobehav Rev. 2010 Sep;35(1):2-16. doi: 10.1016/j.neubiorev.2009.10.002. Epub 2009 Oct 12.

Allostatic load biomarkers of chronic stress and impact on health and cognition.

Author information

1
Laboratory of Psychoneuroendocrinology of the Centre for Studies on Human Stress, Fernand-Seguin Research Centre, University of Montreal, Canada. robert.juster@mail.mcgill.ca

Abstract

The allostatic load model expands the stress-disease literature by proposing a temporal cascade of multi-systemic physiological dysregulations that contribute to disease trajectories. By incorporating an allostatic load index representing neuroendocrine, immune, metabolic, and cardiovascular system functioning, numerous studies have demonstrated greater prediction of morbidity and mortality over and beyond traditional detection methods employed in biomedical practice. This article reviews theoretical and empirical work using the allostatic load model vis-à-vis the effects of chronic stress on physical and mental health. Specific risk and protective factors associated with increased allostatic load are elucidated and policies for promoting successful aging are proposed.

PMID:
19822172
DOI:
10.1016/j.neubiorev.2009.10.002
[Indexed for MEDLINE]

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