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Laryngoscope. 2010 Jan;120(1):178-82. doi: 10.1002/lary.20759.

AM-111 prevents hearing loss from semicircular canal injury in otitis media.

Author information

1
Department of Otolaryngology, University of Florida, Gainesville, Florida 32610-0264, USA.

Abstract

OBJECTIVES/HYPOTHESIS:

Iatrogenic semicircular canal (SC) transection during mastoidectomy for chronic otitis media often leads to profound hearing loss. AM-111, an apoptosis inhibitor, has been shown to mitigate hearing loss resulting from a variety of inner ear injuries. The goal of this study was to determine if round window application of AM-111 following SC transection in the presence of Pseudomonas aeruginosa otitis media (PA-OM) may reduce the associated hearing loss.

STUDY DESIGN:

Prospective, randomized, controlled study in an animal model.

METHODS:

PA-OM was induced bilaterally in 34 guinea pigs. After 3 days, both bullae were opened and the lateral SC of one ear was transected. AM-111 or vehicle was applied topically to the round window of the ear that had undergone SC transection. Hearing was assessed with auditory brainstem responses.

RESULTS:

The mean change in hearing thresholds was significantly less in transected ears treated with AM-111 than those receiving vehicle alone when testing with clicks (22.1 dB vs. 35.0 dB; P = .019) and at 4kHz (11.3 dB vs. 40.0 dB; P = .021). A similar trend was shown with 16 kHz tone pips (27.7 dB vs. 41.1 dB; P = .119).

CONCLUSIONS:

AM-111 prevents hearing loss from SC transection in the guinea pig model of PA-OM.

PMID:
19821539
DOI:
10.1002/lary.20759
[Indexed for MEDLINE]

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