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Nat Genet. 2009 Nov;41(11):1173-5. doi: 10.1038/ng.456. Epub 2009 Oct 11.

Common variants in TMPRSS6 are associated with iron status and erythrocyte volume.

Author information

1
Queensland Institute of Medical Research, Brisbane, Queensland, Australia. bebenB@qimr.edu.au

Abstract

We report a genome-wide association study to iron status. We identify an association of SNPs in TPMRSS6 to serum iron (rs855791, combined P = 1.5 x 10(-20)), transferrin saturation (combined P = 2.2 x 10(-23)) and erythrocyte mean cell volume (MCV, combined P = 1.1 x 10(-10)). We also find suggestive evidence of association with blood hemoglobin levels (combined P = 5.3 x 10(-7)). These findings demonstrate the involvement of TMPRSS6 in control of iron homeostasis and in normal erythropoiesis.

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PMID:
19820699
PMCID:
PMC3135421
DOI:
10.1038/ng.456
[Indexed for MEDLINE]
Free PMC Article

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