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Pediatr Infect Dis J. 2009 Nov;28(11):996-1001. doi: 10.1097/INF.0b013e3181a78348.

Determinants of vaccine immunity in the cohort of human immunodeficiency virus-infected children living in Switzerland.

Author information

1
Department of Pediatrics, Geneva Medical School and University Hospitals of Geneva, Switzerland.

Abstract

BACKGROUND:

Human immunodeficiency virus (HIV)-infected children are at increased risk of infections caused by vaccine preventable pathogens, and specific immunization recommendations have been issued.

METHODS:

A prospective national multicenter study assessed how these recommendations are followed in Switzerland and how immunization history correlates with vaccine immunity.

RESULTS:

Among 87 HIV-infected children (mean age: 11.1 years) followed in the 5 Swiss university hospitals and 1 regional hospital, most (76%) had CD4 T cells >25%, were receiving highly active antiretroviral treatment (79%) and had undetectable viral load (60%). Immunization coverage was lower than in the general population and many lacked serum antibodies to vaccine-preventable pathogens, including measles (54%), varicella (39%), and hepatitis B (65%). The presence of vaccine antibodies correlated most significantly with having an up-to-date immunization history (P<0.05). An up-to-date immunization history was not related to age, immunologic stage, or viremia but to the referral medical center.

CONCLUSIONS:

All pediatricians in charge of HIV-infected children are urged to identify missing immunizations in this high-risk population.

PMID:
19820427
DOI:
10.1097/INF.0b013e3181a78348
[Indexed for MEDLINE]

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