Format

Send to

Choose Destination
J Clin Endocrinol Metab. 2009 Dec;94(12):4696-702. doi: 10.1210/jc.2009-1030. Epub 2009 Oct 9.

Ethnic variation in fat and lean body mass and the association with insulin resistance.

Author information

1
Department of Biomedical Physiology and Kinesiology, Simon Fraser University Harbor Centre Campus, 515 West Hastings Street, Vancouver, British Columbia, Canada V6B 5K3. slear@providencehealth.bc.ca

Abstract

CONTEXT:

Body fat distribution varies among different ethnic groups, yet less is known regarding differences in lean mass and how this may affect insulin resistance.

OBJECTIVE:

Our objective was to compare total body fat to lean mass ratio (F:LM) in Aboriginal, Chinese, European, and South Asian individuals with differences in insulin resistance.

PARTICIPANTS, DESIGN, AND SETTING:

Aboriginal (196), Chinese (222), European (202), and South Asian (208) individuals were recruited across a range of body mass index to participate in this cross-sectional community study.

MAIN OUTCOME MEASURES:

Total body fat, lean mass, and insulin resistance were assessed using homeostasis model assessment (HOMA).

RESULTS:

After adjustment for confounders and at a given body fat, South Asian men had less lean mass than Aboriginal [3.42 kg less; 95% confidence interval (CI) = 1.55-5.29], Chinese (3.01 kg less; 95% CI = 1.33-4.70), and European (3.57 kg less; 95% CI = 1.82-5.33) men, whereas South Asian women had less lean mass than Aboriginal (1.98 kg less; 95% CI = 0.45-3.50), Chinese (2.24 kg less; 95% CI = 0.81-3.68), and European (2.97 kg less; 95% CI = 1.67-4.27) women. In adjusted models, F:LM was higher in South Asian compared with Chinese and European men and higher in South Asian compared with Aboriginal, Chinese, and European women (P < 0.01 for all). Insulin and HOMA were greatest in South Asians after adjustment; however, these differences were no longer apparent when F:LM was considered.

CONCLUSIONS:

South Asians have a phenotype of high fat mass and low lean mass, which may account for greater levels of insulin and HOMA compared with other ethnic groups.

PMID:
19820012
DOI:
10.1210/jc.2009-1030
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Silverchair Information Systems
Loading ...
Support Center