Format

Send to

Choose Destination
See comment in PubMed Commons below
FEBS Lett. 2009 Nov 3;583(21):3412-8. doi: 10.1016/j.febslet.2009.09.056. Epub 2009 Oct 9.

Delta(9)-tetrahydrocannabinol regulates the p53 post-translational modifiers Murine double minute 2 and the Small Ubiquitin MOdifier protein in the rat brain.

Author information

1
Department of Physiology, Trinity College Institute of Neuroscience, Trinity College, Dublin 2, Ireland. gowrana@tcd.ie

Erratum in

  • FEBS Lett. 2010 Jan 4;584(1):239.

Abstract

The phytocannabinoid Delta(9)-Tetrahydrocannabinol (Delta(9)-THC), the main psychoactive cannabinoid in cannabis, activates a number of signalling cascades including p53. This study examines the role of Delta(9)-THC in regulating the p53 post-translational modifier proteins, Murine double minute (Mdm2) and Small Ubquitin-like MOdifier protein 1 (SUMO-1) in cortical neurons. Delta(9)-THC increased both Mdm2 and SUMO-1 protein expression and induced the deSUMOylation of p53 in a cannabinoid receptor type 1 (CB(1))-receptor dependent manner. We demonstrate that Delta(9)-THC decreased the SUMOylation of the CB(1) receptor. The data reveal a novel role for cannabinoid receptor activation in modulating the SUMO regulatory system.

PMID:
19819240
DOI:
10.1016/j.febslet.2009.09.056
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center