Format

Send to

Choose Destination
See comment in PubMed Commons below
Curr Biol. 2009 Nov 17;19(21):1811-5. doi: 10.1016/j.cub.2009.09.026. Epub 2009 Oct 8.

An ancient anterior patterning system promotes caudal repression and head formation in ecdysozoa.

Author information

1
Developmental Biology, Department of Biology, University of Erlangen-Nürnberg, 91058 Erlangen, Germany.

Abstract

Posterior expression of Caudal is required for early embryonic development in nematodes, arthropods, and vertebrates. In Drosophila, ectopic Caudal in anterior cells can induce head defects, and in Caenorhabditis the absence of Caudal in anterior embryonic cells is required for proper development. Anterior Caudal repression in these species is achieved through unrelated translational repressors, the homeodomain protein Bicoid and the KH domain factor Mex-3, respectively. Here we report that the Mex-3 ortholog in the flour beetle Tribolium plays a crucial role in head formation and that Caudal in this species is repressed by the combined activities of Mex-3 and Zen-2, a protein sharing common ancestry with the dipteran morphogen Bicoid. We propose that Mex-3 represents an ancient "anterior" promoting factor common to all Ecdysozoa (and maybe all Bilateria), whose role has been usurped in higher dipterans by Bicoid.

PMID:
19818622
DOI:
10.1016/j.cub.2009.09.026
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center