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Bioorg Med Chem Lett. 2009 Nov 15;19(22):6368-72. doi: 10.1016/j.bmcl.2009.09.066. Epub 2009 Sep 22.

Optimization of azepanone calcitonin gene-related peptide (CGRP) receptor antagonists: development of novel spiropiperidines.

Author information

1
Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA 19486, USA. christopher_burgey@merck.com

Abstract

Several novel spiropiperidine-based CGRP receptor antagonists have been developed that maintain good potency and have reduced potential for metabolism.

PMID:
19818613
DOI:
10.1016/j.bmcl.2009.09.066
[Indexed for MEDLINE]

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