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J Med Chem. 2009 Nov 12;52(21):6931-5. doi: 10.1021/jm900823s.

Phenoxy herbicides and fibrates potently inhibit the human chemosensory receptor subunit T1R3.

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1
Department of Neuroscience, Mount Sinai School of Medicine, New York, New York 10029, USA.

Abstract

We show that phenoxyauxin herbicides and lipid-lowering fibrates inhibit human but not rodent T1R3. T1R3 as a coreceptor in taste cells responds to sweet compounds and amino acids; in endocrine cells of gut and pancreas T1R3 contributes to glucose sensing. Thus, certain effects of fibrates in treating hyperlipidemia and type II diabetes may be via actions on T1R3. Likewise, phenoxy herbicides may have adverse metabolic effects in humans that would have gone undetected in studies on rodents.

PMID:
19817384
PMCID:
PMC2783803
DOI:
10.1021/jm900823s
[Indexed for MEDLINE]
Free PMC Article

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