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Pharmacol Rep. 2009 Jul-Aug;61(4):595-603.

Role of NF-kappa B in the pathogenesis of diabetes and its associated complications.

Author information

1
Department of Pharmacology, Indukaka Ipcowala College of Pharmacy, New Vallabh Vidyanagar, Anand, Gujarat 388121, India. patelsandozrx@gmail.com

Abstract

The nuclear factor-kappaB (NF-kappaB) family is comprised of DNA-binding protein factors that are required for the transcription of most proinflammatory molecules, including adhesion molecules, enzymes, cytokines, and chemokines. Studies performed in a variety of cell and animal based experimental systems suggest that NF-kappaB activation is a key event early in the pathobiology of diabetes. The purpose of this review is to summarize the current knowledge about the molecular biology of NF-kappaB and to review evidence that implicates NF-kappaB in the pathogenesis of diabetes and its associated complications.

PMID:
19815941
DOI:
10.1016/s1734-1140(09)70111-2
[Indexed for MEDLINE]
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