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Physiology (Bethesda). 2009 Oct;24:290-7. doi: 10.1152/physiol.00016.2009.

Oligodendrocyte development and myelin biogenesis: parsing out the roles of glycosphingolipids.

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1
Department of Neuroscience, University of Connecticut Medical School, Farmington, Connecticut, USA.

Abstract

The myelin sheath is an extension of the oligoddendrocyte (OL) plasma membrane enriched in lipids that ensheaths the axons of the central and peripheral nervous system. Here, we review the involvement of glycosphingolipids in myelin/OL functions, including the regulation of OL differentiation, lipid raft-mediated trafficking and signaling, and neuron-glia interactions.

PMID:
19815855
PMCID:
PMC2854184
DOI:
10.1152/physiol.00016.2009
[Indexed for MEDLINE]
Free PMC Article
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