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Clin Infect Dis. 2009 Nov 1;49(9):e96-9. doi: 10.1086/644501.

The R753Q polymorphism abrogates toll-like receptor 2 signaling in response to human cytomegalovirus.

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1
Division of Infectious Diseases, College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.

Abstract

Toll-like receptor 2 (TLR2) serves as a pattern recognition receptor that signals the presence of cytomegalovirus. Herein, we report that R753Q polymorphism paralyzes TLR2-mediated immune signaling in cells exposed to cytomegalovirus glycoprotein B. This immunologic impairment could serve as a biologic mechanism underlying the association between the TLR2 R753Q polymorphism and cytomegalovirus disease in humans.

PMID:
19814623
PMCID:
PMC2761976
DOI:
10.1086/644501
[Indexed for MEDLINE]
Free PMC Article
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