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Org Lett. 2009 Nov 5;11(21):5014-7. doi: 10.1021/ol901996g.

Epoxyphomalin A and B, prenylated polyketides with potent cytotoxicity from the marine-derived fungus Phoma sp.

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1
Department of Botany, University of Khartoum, Khartoum, Sudan.

Abstract

Chemical investigation of a strain of the marine-derived fungus Phoma sp. has led to the discovery of epoxyphomalin A (1) and B (2), two new prenylated polyketides with unusual structural features. Epoxyphomalin A (1) showed superior cytotoxicity at nanomolar concentrations toward 12 of a panel of 36 human tumor cell lines. In COMPARE analyses, the observed cytotoxic selectivity pattern of 1 did not correlate with those of reference anticancer agents with known mechanisms of action.

PMID:
19813715
DOI:
10.1021/ol901996g
[Indexed for MEDLINE]
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