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Phytother Res. 2010 Apr;24(4):583-6. doi: 10.1002/ptr.2990.

Effects of acacia honey on wound healing in various rat models.

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Department of Honey Bee Research, National Agricultural Research Council, PO NARC, Park Road, Islamabad, Pakistan.


Honey is a traditional remedy for the treatment of infected wounds, and is becoming more important as microbial resistance to conventional therapeutic agents increases. A study was conducted to assess the wound-healing activity of Acacia honey using incision, excision, burn and dead-space wound models in rats. Different formulations of honey were used and rats were treated topically as well as orally. Both the higher and lower doses of honey produced a significant effect on healing (p < 0.05). The area of epithelization was found to increase, followed by an increase in wound contraction, skin-breaking strength, tissue granulation. The hydroxyproline content also increased in the rats treated with higher doses of honey compared to control, indicating an increase in collagen formation.

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