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Mol Cells. 2009 Oct 31;28(4):315-20. doi: 10.1007/s10059-009-0143-7. Epub 2009 Sep 30.

Non-redundancy within the RAS oncogene family: insights into mutational disparities in cancer.

Author information

1
Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital and Department of Pathology, Harvard Medical School, Boston, USA.

Abstract

The RAS family of oncoproteins has been studied extensively for almost three decades. While we know that activation of RAS represents a key feature of malignant transformation for many cancers, we are only now beginning to understand the complex underpinnings of RAS biology. Here, we will discuss emerging cancer genome sequencing data in the context of what is currently known about RAS function. Taken together, retrospective studies of primary human tissues and prospective studies of experimental models support the notion that the variable mutation frequencies exhibited by the RAS oncogenes reflect unique functions of the RAS oncoproteins.

PMID:
19812895
PMCID:
PMC3976423
DOI:
10.1007/s10059-009-0143-7
[Indexed for MEDLINE]
Free PMC Article

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