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Am J Clin Nutr. 2009 Dec;90(6):1509-16. doi: 10.3945/ajcn.2009.27601. Epub 2009 Oct 7.

Effect of short-term high-protein compared with normal-protein diets on renal hemodynamics and associated variables in healthy young men.

Author information

1
Klinikum rechts der Isar, Technical University Munich, Munich, Germany. helga.frank@lrz.tum.de

Erratum in

  • Am J Clin Nutr. 2010 Feb;91(2):494. Graf, Juliane [corrected to Graf, Julia].

Abstract

BACKGROUND:

High-protein diets are effective for weight reduction; however, little is known about the potential adverse renal effects of such diets.

OBJECTIVE:

The aim of our study was to compare the effect of a high-protein (HP) with a normal-protein (NP) diet on renal hemodynamics and selected clinical-chemical factors.

DESIGN:

We prospectively studied the effect of an HP diet (2.4 g x kg(-1) x d(-1)) with that of an NP diet (1.2 g x kg(-1) x d(-1)) on the glomerular filtration rate (assessed on the basis of sinistrin-an inulin analog-clearance) and renal plasma flow (para-aminohippuric acid clearance) by using the constant infusion technique. Filtration fraction and renal vascular resistance were calculated. Twenty-four healthy young men followed the 2 diet protocols for 7 d each in a crossover design. They were individually advised by a dietitian to achieve the planned protein intake by selecting normal foods under isocaloric conditions. Serum and urinary variables and renal hemodynamics were measured on day 7 of both diets.

RESULTS:

The glomerular filtration rate (NP: 125 +/- 5 mL/min; HP: 141 +/- 8 mL/min; P < 0.001) and filtration fraction (NP: 23 +/- 5%; HP: 28 +/- 5%; P < 0.05) increased significantly with the HP diet. Renal plasma flow was not significantly different between the HP (496 +/- 25 mL/min) and NP (507 +/- 18 mL/min) phases. Renal vascular resistance was not significantly different between the NP (94 +/- 6 mm Hg x mL(-1) x min(-1)) and HP (99 +/- 8 mm Hg x mL(-1) x min(-1)) phases. Blood urea nitrogen, serum uric acid, glucagon, natriuresis, urinary albumin, and urea excretion increased significantly with the HP diet.

CONCLUSIONS:

A short-term HP diet alters renal hemodynamics and renal excretion of uric acid, sodium, and albumin. More attention should be paid to the potential adverse renal effects of HP diets.

PMID:
19812175
DOI:
10.3945/ajcn.2009.27601
[Indexed for MEDLINE]

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