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Int Rev Immunol. 2009;28(3-4):239-60. doi: 10.1080/08830180902978120.

Molecular mechanisms of IFN-gamma to up-regulate MHC class I antigen processing and presentation.

Author information

1
Diamantina Institute for Cancer Immunology and Metabolic Medicine, Princess Alexandra Hospital, University of Queensland, Brisbane, QLD, Australia. f.zhou@uq.edu.au

Abstract

IFN-gamma up-regulates MHC class I expression and antigen processing and presentation on cells, since IFN-gamma can induce multiple gene expressions that are related to MHC class I antigen processing and presentation. MHC class I antigen presentation-associated gene expression is initiated by IRF-1. IRF-1 expression is initiated by phosphorylated STAT1. IFN-gamma binds to IFN receptors, and then activates JAK1/JAK2/STAT1 signal transduction via phosphorylation of JAK and STAT1 in cells. IFN-gamma up-regulates MHC class I antigen presentation via activation of JAK/STAT1 signal transduction pathway. Mechanisms of IFN-gamma to enhance MHC class I antigen processing and presentation were summarized in this literature review.

PMID:
19811323
DOI:
10.1080/08830180902978120
[Indexed for MEDLINE]

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