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Autoimmunity. 2009 May;42(4):373-5.

Do B cells play a role in the pathogenesis of juvenile idiopathic arthritis?

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Pediatric Rheumatology, Immunology and Infectious Diseases, Children's Hospital, University of Würzburg, Würzburg, Germany.


Juvenile idiopathic arthritis (JIA) is the most common cause of chronic arthritis in childhood and adolescents and encompasses a heterogeneous group of diseases. The role of B cells (BC) in autoimmune diseases has been put in a new perspective due to the promising results of BC depleting therapies in RA. Experiments in mouse models have shed new light on the Ab-independent role of BC in the pathogenesis of autoimmune diseases. We discuss whether BC play a role in the pathogenesis of JIA appraising the question for an immunological basis of BC directed therapy.

[Indexed for MEDLINE]

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