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Immunol Lett. 1990 Aug;25(1-3):101-7.

The role of CD4+ T cells in the protective immune response to Plasmodium chabaudi in vivo.

Author information

1
Max-Planck-Institut für Immunbiologie, Freiburg, F.R.G.

Abstract

CD4+ T cells are an essential component of the protective immune response to Plasmodium chabaudi. In order to determine whether the presence of CD4+ T cells is necessary throughout a primary infection for a protective immune response to develop mice were depleted of their CD4+ T cells in vivo by treatment with specific antibodies. Removal of CD4+ T cells during the acute phase of infection renders mice incapable of clearing their infection. In contrast, removal of CD4+ T cells after this time did not affect their ability to control their parasitaemia. The ability to control parasitaemia correlated with appearance of malaria-specific IgG antibodies. Our data, therefore, suggest a mechanism requiring the presence of CD4+ T cells during the acute pre-IgG period. Later, after IgG has been produced, this mechanism is no longer required.

PMID:
1980906
DOI:
10.1016/0165-2478(90)90099-c
[Indexed for MEDLINE]

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