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J Exp Med. 2009 Oct 26;206(11):2417-27. doi: 10.1084/jem.20090097. Epub 2009 Sep 28.

Staphylococcus aureus synthesizes adenosine to escape host immune responses.

Author information

1
Department of Microbiology, University of Chicago, Chicago, IL 60637, USA.

Abstract

Staphylococcus aureus infects hospitalized or healthy individuals and represents the most frequent cause of bacteremia, treatment of which is complicated by the emergence of methicillin-resistant S. aureus. We examined the ability of S. aureus to escape phagocytic clearance in blood and identified adenosine synthase A (AdsA), a cell wall-anchored enzyme that converts adenosine monophosphate to adenosine, as a critical virulence factor. Staphylococcal synthesis of adenosine in blood, escape from phagocytic clearance, and subsequent formation of organ abscesses were all dependent on adsA and could be rescued by an exogenous supply of adenosine. An AdsA homologue was identified in the anthrax pathogen, and adenosine synthesis also enabled escape of Bacillus anthracis from phagocytic clearance. Collectively, these results suggest that staphylococci and other bacterial pathogens exploit the immunomodulatory attributes of adenosine to escape host immune responses.

PMID:
19808256
PMCID:
PMC2768845
DOI:
10.1084/jem.20090097
[Indexed for MEDLINE]
Free PMC Article

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