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APMIS. 1990 Dec;98(12):1077-84.

The proliferative response of peripheral blood mononuclear cells to streptokinase. A study of patients receiving a single intravenous infusion of purified streptokinase.

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Medical Department B, Haukeland University Hospital, Bergen, Norway.


In vitro proliferative PBM responses were investigated for 26 patients with and 5 patients without acute myocardial infarction. All patients were initially treated with streptokinase (1.5 MIU infused for 1 hour). Five weeks after the disease increased responses to streptokinase, PPD and PHA were seen; but only for streptokinase had original nonresponders become responders (7 out of 14 nonresponders). The increased responsiveness to streptokinase could be detected five days after antigen infusion, and CD-2 positive cells constituted a major part of the proliferating PBM population. The responses after antigen infusion varied within a wide range both for patients with and without myocardial infarction.

[Indexed for MEDLINE]

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