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Trends Genet. 1990 Oct;6(10):323-9.

The structure of the homeodomain and its functional implications.

Author information

1
University of Basel, Switzerland.

Abstract

The three-dimensional structure of the homeodomain, as determined by nuclear magnetic resonance spectroscopy, reveals the presence of a helix-turn-helix motif, similar to the one found in prokaryotic gene regulatory proteins. Isolated homeodomains bind with high affinity to specific DNA sequences. Thus, the structure-function relationship is highly conserved in evolution.

PMID:
1980756
[Indexed for MEDLINE]

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