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PLoS One. 2009 Oct 6;4(10):e7225. doi: 10.1371/journal.pone.0007225.

MicroRNAs show mutually exclusive expression patterns in the brain of adult male rats.

Author information

1
Institute for Biological Psychiatry, Psychiatric Centre Sct. Hans, Roskilde, Denmark.

Abstract

BACKGROUND:

The brain is a major site of microRNA (miRNA) gene expression, but the spatial expression patterns of miRNAs within the brain have not yet been fully covered.

METHODOLOGY/PRINCIPAL FINDINGS:

We have characterized the regional expression profiles of miRNAs in five distinct regions of the adult rat brain: amygdala, cerebellum, hippocampus, hypothalamus and substantia nigra. Microarray profiling uncovered 48 miRNAs displaying more than three-fold enrichment between two or more brain regions. Notably, we found reciprocal expression profiles for a subset of the miRNAs predominantly found (> ten times) in either the cerebellum (miR-206 and miR-497) or the forebrain regions (miR-132, miR-212, miR-221 and miR-222).

CONCLUSIONS/SIGNIFICANCE:

The results indicate that some miRNAs could be important for area-specific functions in the brain. Our data, combined with previous studies in mice, provides additional guidance for future investigations of miRNA functions in the brain.

PMID:
19806225
PMCID:
PMC2752988
DOI:
10.1371/journal.pone.0007225
[Indexed for MEDLINE]
Free PMC Article

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