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Nat Rev Microbiol. 2009 Nov;7(11):822-7. doi: 10.1038/nrmicro2202. Epub 2009 Oct 6.

Metabolism, cell growth and the bacterial cell cycle.

Author information

1
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA. jdwang@bcm.edu

Abstract

Adaptation to fluctuations in nutrient availability is a fact of life for single-celled organisms in the 'wild'. A decade ago our understanding of how bacteria adjust cell cycle parameters to accommodate changes in nutrient availability stemmed almost entirely from elegant physiological studies completed in the 1960s. In this Opinion article we summarize recent groundbreaking work in this area and discuss potential mechanisms by which nutrient availability and metabolic status are coordinated with cell growth, chromosome replication and cell division.

PMID:
19806155
PMCID:
PMC2887316
DOI:
10.1038/nrmicro2202
[Indexed for MEDLINE]
Free PMC Article
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