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J Biosci Bioeng. 2009 Nov;108(5):446-9. doi: 10.1016/j.jbiosc.2009.05.005.

Insertional chromatin immunoprecipitation: a method for isolating specific genomic regions.

Author information

1
Department of Pathology, New York University School of Medicine, New York, NY 10016, USA.

Abstract

We established a novel method, insertional chromatin immunoprecipitation (iChIP), for isolation of specific genomic regions. In iChIP, specific genomic domains are immunoprecipitated with antibody against a tag, which is fused to the DNA-binding domain of an exogenous DNA-binding protein, whose recognition sequence is inserted into the genomic domains of interest. The iChIP method will be a useful tool for dissecting chromatin structure of genomic region of interest.

PMID:
19804873
DOI:
10.1016/j.jbiosc.2009.05.005
[Indexed for MEDLINE]

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