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Genomics. 1990 Dec;8(4):648-55.

Manic depressive illness not linked to factor IX region in an independent series of pedigrees.

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Clinical Neurogenetics Branch, National Institute of Mental Health, Bethesda, Maryland 20892.


We studied seven informative kindreds segregating for manic depressive illness (MDI), consistent with X-chromosome transmission of the trait (families do not show affective disease in both a father and a son), using markers mapped to the region of Xq27-Xq28. The lod scores were consistently below -2 in the region extending from about 10 cM centromeric from the Factor IX locus (F9) to the colorblindness region. This study does not replicate previous reports of linkage of MDI to Factor IX (Xq27) and colorblindness region (Xq28) chromosomal markers in other kindreds.

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