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Cell. 2009 Oct 2;139(1):25-7. doi: 10.1016/j.cell.2009.09.017.

DNA double-strand breaks come into focus.

Author information

1
Center for Integrated Protein Science Munich and Munich Center for Advanced Photonics at the Gene Center, Department of Chemistry and Biochemistry, Ludwig-Maximilians-University Munich, 81377 Munich, Germany. hopfner@lmb.uni-muenchen.de

Abstract

The Mre11-Rad50-Nbs1 (MRN) complex senses DNA double-strand breaks and recruits different repair pathway and checkpoint proteins to break foci. Two new studies (Williams et al., 2009; Lloyd et al., 2009) identify Nbs1 as a key factor in this process and reveal how an N-terminal protein recruitment module in Nbs1 binds to different response factors through shared phosphopeptide motifs.

PMID:
19804750
DOI:
10.1016/j.cell.2009.09.017
[Indexed for MEDLINE]
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