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Expert Rev Anti Infect Ther. 2009 Oct;7(8):1015-26. doi: 10.1586/eri.09.76.

Hyperbaric oxygen therapy as an anti-infective agent.

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Department of Underwater and Hyperbaric Medicine, Istanbul University, Medical Faculty, Istanbul, Turkey.


Hyperbaric oxygen therapy (HBOT) involves inhalation of 100% oxygen at supra-atmospheric ambient pressure. HBOT is used as either a primary or adjunctive treatment in the management of infections such as gas gangrene, necrotizing fasciitis, diabetic foot infections, refractory osteomyelitis, neurosurgical infections and fungal infections. HBOT acts as a bactericidal/bacteriostatic agent against anerobic bacteria by increasing the formation of free oxygen radicals. HBOT restores the bacterial-killing capacity of leukocytes in hypoxic wounds by increasing tissue oxygen tensions. In addition, HBOT acts synergistically with a number of antibiotics. This article reviews the anti-infective effects of HBOT and the use of HBOT in the treatment of certain infectious diseases.

[Indexed for MEDLINE]

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