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Ross Fiziol Zh Im I M Sechenova. 2009 Jul;95(7):750-61.

[Local GABA-ergic modulation of serotonergic neuron activity in the nucleus raphe magnus].

[Article in Russian]

Abstract

In voltage-clamp experimental on slices of the rat brainstem the effects of 5-HT and GABA on serotonergic neurons of nucleus raphe magnus were investigated. Local applications of 5-HT induced an increase in IPCSs frequency and amplitude in 45% of serotonergic cells. The effect suppressed by the blocker of fast sodium channels tetradotoxin. Antagonist of GABA receptor gabazine blocked IPSCs in neurons both sensitive and non-sensitive to 5-HT action. Applications of GABA induced a membrane current (I(GABA)), which was completely blocked by gabazine. The data suggest self-control of the activity of serotonergic neurons in nucleus raphe magnus by negative feedback loop via local GABAergic interneurons.

PMID:
19803461
[Indexed for MEDLINE]
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