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FEBS Lett. 1990 Dec 17;277(1-2):250-2.

Conservation of engrailed-like homeobox sequences during vertebrate evolution.

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1
Department of Zoology, University of Oxford, UK.

Abstract

The Drosophila melanogaster developmental gene engrailed (en) is a member of a distinct subfamily of homeobox genes with a wide phylogenetic distribution. Here we report the use of reduced stringency polymerase chain reaction (PCR) to amplify and clone 8 genes related to en from 5 vertebrate species, including representatives of the most ancient vertebrate lineages. Nucleotide and deduced amino acid sequence comparisons between mouse, toad, zebrafish, lamprey and hagfish genes reveal extensive evolutionary conservation, and suggests that 2 en-like genes have been retained in most vertebrate lineages.

PMID:
1980115
DOI:
10.1016/0014-5793(90)80858-g
[Indexed for MEDLINE]
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