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J Neuroimmunol. 2009 Nov 30;216(1-2):126-9. doi: 10.1016/j.jneuroim.2009.09.005. Epub 2009 Oct 2.

Decreased cellular IL-23 but not IL-17 production in children with autism spectrum disorders.

Author information

1
Department of Medical Microbiology and Immunology, University of California at Davis, USA. pashwood@ucdavis.edu

Abstract

A potential role for T(H)17 cells has been suggested in a number of conditions including neurodevelopmental disorders such as autism spectrum disorders (ASD). In the current study, we investigated cellular release of IL-17 and IL-23 following an in-vitro immunological challenge of peripheral blood mononuclear cells (PBMC) from children with ASD compared to age-matched typically developing controls. Following stimulation, the concentration of IL-23, but not IL-17, was significantly reduced (p=0.021) in ASD compared to controls. Decreased cellular IL-23 production in ASD warrants further research to determine its role on the generation and survival of T(H)17 cells, a cell subset important in neuroinflammatory conditions that may include ASD.

PMID:
19800697
PMCID:
PMC2981175
DOI:
10.1016/j.jneuroim.2009.09.005
[Indexed for MEDLINE]
Free PMC Article
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