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J Cyst Fibros. 2009 Dec;8(6):382-5. doi: 10.1016/j.jcf.2009.08.006. Epub 2009 Oct 2.

Evaluation of salt supplementation in CF infants.

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1
Royal Hospital for Sick Children, Edinburgh EH91LF, UK. alison.coates@luht.scot.nhs.uk

Abstract

BACKGROUND:

CF infants may be at increased risk of sodium depletion which may lead to impaired growth. The objective of this study was to evaluate their sodium supplementation requirements.

METHODS:

Ten CF infants had serial measurements of weight and plasma/urine sodium and creatinine. Sodium supplementation was adjusted with the aim of maintaining fractional excretion (FENa) between 0.5% and 1.5% and urinary sodium > 10 mmol/L.

RESULTS:

Urine sodium:creatinine (UNa:Cr) ratio strongly correlated with FENa [UNa:Cr (mmol/mmol)=35.0 x FENa (r=0.99)]. The FENa target range corresponded to UNa:Cr 17-52 mmol/mmol. All infants required sodium supplementation to achieve UNa:Cr > 17 mmol/mmol. Sodium supplement requirements (mean+/-SD) at ages 0-3, 3-6, 6-9 and 9-12 months were 1.9+/-0.5, 1.8+/-0.8, 1.9+/-0.9 and 0.8+/-0.4 mmol/kg/d. No infant required calorie supplementation to achieve expected weight gain.

CONCLUSIONS:

Using current UK guidelines, many cases of sodium depletion may be overlooked. Some infants require more than the recommended 1-2 mmol/kg/d. UNa:Cr ratio is a useful non-invasive measure to monitor sodium supplementation.

PMID:
19800301
DOI:
10.1016/j.jcf.2009.08.006
[Indexed for MEDLINE]
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