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Fitoterapia. 2010 Jun;81(4):259-68. doi: 10.1016/j.fitote.2009.09.012. Epub 2009 Sep 30.

Inhibitory effect and transcriptional impact of berberine and evodiamine on human white preadipocyte differentiation.

Author information

1
Department of Pharmaceutical Sciences, College of Pharmacy, South Dakota State University, Brookings, SD 57007, USA.

Abstract

It has been reported that the botanical alkaloids, berberine and evodiamine inhibit mouse preadipocyte 3T3-L1 differentiation. The aim of this study was to investigate the effect and transcriptional impact of berberine and evodiamine individually and in combination on human white preadipocyte (HWP) differentiation. We have shown that treatment with 8 microM berberine or 4 microM evodiamine resulted in a major inhibition of HWP differentiation accompanied by up-regulation of both GATA binding protein 2 and 3 (GATA-2 and GATA-3) mRNA and protein expression, suggesting that both compounds may have excellent potential as agents to prevent obesity.

PMID:
19799972
DOI:
10.1016/j.fitote.2009.09.012
[Indexed for MEDLINE]

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