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Nat Rev Rheumatol. 2009 Oct;5(10):560-5. doi: 10.1038/nrrheum.2009.183.

Regulatory T cells as therapeutic targets in rheumatoid arthritis.

Author information

1
Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA.

Abstract

Regulatory T cells (TREG) are a subset of CD4+ T cells with a critical role in the prevention of autoimmunity. Whether defects in TREG contribute to the pathogenesis of rheumatoid arthritis (RA) is unclear. However, a variety of approved and experimental drugs for RA may work, in part, by promoting the function or increasing numbers of TREG. Furthermore, animal studies demonstrate that direct injection of TREG ameliorates a wide range of experimental models of inflammatory and autoimmune diseases. Thus, cell-based therapy with TREG has the potential to produce durable disease remission in patients with RA.

PMID:
19798031
PMCID:
PMC3086064
DOI:
10.1038/nrrheum.2009.183
[Indexed for MEDLINE]
Free PMC Article

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