Format

Send to

Choose Destination
Nephron Clin Pract. 2010;114(1):c1-4. doi: 10.1159/000242442. Epub 2009 Oct 1.

Case-control studies--an efficient observational study design.

Author information

1
Department of Medical Informatics J1b, Academic Medical Center, Amsterdam, The Netherlands.

Abstract

Case-control studies are an efficient research method for investigating risk factors of a disease. The method involves the comparison of the odds of exposure in a patient group with that of the odds of exposure in a control group. As only a minority of the population is included in the study, less time can be devoted to those who remain free of the disease of interest. The design of a case-control study can be complex due to the selection of the appropriate cases and controls. Cases can be identified in a prospective and retrospective manner from various sources. Controls can be obtained via the patient, random digit dialing or in a hospital and all at different points in the time period of the study. All options have their own advantages and disadvantages. Furthermore, different forms of bias, such as recall bias and selection bias, can occur. When appropriately designed, case-control studies can provide the same information as in a cohort study, in a more rapid and efficient manner.

PMID:
19797931
DOI:
10.1159/000242442
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for S. Karger AG, Basel, Switzerland
Loading ...
Support Center