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Genes Dev. 2009 Oct 1;23(19):2278-83. doi: 10.1101/gad.535409.

Integrin-linked kinase controls vascular wall formation by negatively regulating Rho/ROCK-mediated vascular smooth muscle cell contraction.

Author information

1
Vascular Development Laboratory, UK London Research Institute, London WC2A 3PX, United Kingdom.

Abstract

Vascular smooth muscle cells (VSMCs) form contractile layers around larger blood vessels in a process that is essential for the formation of a fully functional vasculature. Here, we show that integrin-linked kinase (ILK) is required for the formation of a unitary layer of aligned VSMCs around arterioles and the regulation of blood vessel constriction in mice. In the absence of ILK, activated Rho/ROCK signaling induces the elevated phosphorylation of myosin light chain leading to abnormally enhanced VSMC contraction in vitro and in vivo. Our findings identify ILK as a key component regulating vascular wall formation by negatively modulating VSMC contractility.

PMID:
19797768
PMCID:
PMC2758749
DOI:
10.1101/gad.535409
[Indexed for MEDLINE]
Free PMC Article

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