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Genes Dev. 2009 Oct 1;23(19):2253-9. doi: 10.1101/gad.1858009.

Autophagy for the avoidance of neurodegeneration.

Author information

  • 1Institute of Molecular Biosciences, University of Graz, 8010 Graz, Austria. frank.madeo@uni-graz.at

Abstract

Cellular defense mechanisms, including the unfolded protein response (UPR) and autophagy, attempt to resolve toxic protein aggregates, which are common denominators of neurodegenerative diseases. In this issue of Genes & Development, Hetz and colleagues (pp. 2294-2306) surprisingly show that inhibition of the UPR by knockout of XBP-1 causes a massive increase in autophagy, enhances clearance of superoxide dismutase 1 (SOD1) aggregates, and delays the development of amyotrophic lateral sclerosis. These findings suggest the existence of a homeostatic-if not hormetic-balance between distinct cellular defense mechanisms.

PMID:
19797764
PMCID:
PMC2758740
DOI:
10.1101/gad.1858009
[PubMed - indexed for MEDLINE]
Free PMC Article
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